Saturday, January 27, 2007
Nature:Nigel Goldenfeld and Carl Woese
It is becoming clear that microorganisms have a remarkable ability to reconstruct their genomes in the face of dire environmental stresses, and that in some cases their collective interactions with viruses may be crucial to this. In such a situation, how valid is the very concept of an organism in isolation? It seems that there is a continuity of energy flux and informational transfer from the genome up through cells, community, virosphere and environment. We would go so far as to suggest that a defining characteristic of life is the strong dependency on flux from the environment — be it of energy, chemicals, metabolites or genes. Nowhere are the implications of collective phenomena, mediated by HGT, so pervasive and important as in evolution. A computer scientist might term the cell's translational apparatus (used to convert genetic information to proteins) an 'operating system', by which all innovation is communicated and realized. The fundamental role of translation, represented in particular by the genetic code, is shown by the clearly documented optimization of the code. Its special role in any form of life leads to the striking prediction that early life evolved in a lamarckian way, with vertical descent marginalized by the more powerful early forms of HGT. Refinement through the horizontal sharing of genetic innovations would have triggered an explosion of genetic novelty, until the level of complexity required a transition to the current era of vertical evolution. Thus, we regard as regrettable the conventional concatenation of Darwin's name with evolution, because other modalities must also be considered. This is an extraordinary time for biology, because the perspective we have indicated places biology within a context that must necessarily engage other disciplines more strongly aware of the importance of collective phenomena. Questions suggested by the generic energy, information and gene flows to which we have alluded will probably require resolution in the spirit of statistical mechanics and dynamical systems theory. In time, the current approach of post-hoc modelling will be replaced by interplay between quantitative prediction and experimental test, nowadays more characteristic of the physical sciences. Sometimes, language expresses ignorance rather than knowledge, as in the case of the word 'prokaryote', now superseded by the terms archaea and bacteria. We foresee that in biology, new concepts will require a new language, grounded in mathematics and the discoveries emerging from the data we have highlighted. During an earlier revolution, Antoine Lavoisier observed that scientific progress, like evolution, must overcome a challenge of communication: "We cannot improve the language of any science without at the same time improving the science itself; neither can we, on the other hand, improve a science without improving the language or nomenclature which belongs to it." Biology is about to meet this challenge.
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